Liverpool, Manchester City, Tottenham and Chelsea have qualified from their groups and are now awaiting news of their opponents in the knockout phase.
The draw is scheduled to begin on Monday at 11am and is taking place at the UEFA headquarters in Nyon, Switzerland.
Teams can’t face their group stage rivals or clubs from their own association, meaning there will not be any Premier League clashes at this stage.
But some high-profile ties are set to be drawn with a host of top European clubs in the pot.
Here’s who the Premier League big guns could get.