Once again at their new stadium, Spurs have to do without Dele Alli and Harry Kane who were both injured in their Champions League win over Manchester City.
Match-winner Heung-Min Son is only given a place on the bench, presumably rested for the second leg of their European quarter-final.
This means Fernando Llorente is given the nod up top, with Lucas Moura also finding a place in the XI.
Victor Wanyama makes a rare start along with Kyle Walker-Peters, who will play at right wing-back.
Pochettino has also decided on a back-three, as he has done previously against the Terriers, with Juan Foyth and Davinson Sanchez coming into the team and Toby Alderweireld dropping out.