Springbok scrum-half Ross Cronje will captain the Golden Lions when they tackle the Griquas at Ellis Park in Johannesburg on Friday.
Cronje and Marvin Orie were not part of Bok coach Rassie Erasmus’ revamped 28-man squad to travel to Mendoza to face Argentina on Saturday.
Both will turn out for the Lions this weekend along with fellow fringe Springboks in Andries Coetzee and Courtnall Skosan.
The Lions open their campaign having missed the opening weekend, while the Griquas lost 42-19 to the Pumas.
Golden Lions: 15 Andries Coetzee, 14 Sylvian Mahuza, 13 Jan-Louis la Grange, 12 Manni Rass, 11 Courtnall Skosan, 10 Shaun Reynolds, 9 Ross Cronje (c), 8 Hacjivah Dayimani, 7 Len Massyn, 6 James Venter, 5 Marvin Orie, 4 Rhyno Herbst, 3 Johannes Jonker, 2 Corne Fourie, 1 Sti Sithole
Replacements: 16 HP van Schoor, 17 Jacobie Adriaanse, 18 PJ Steenkamp, 19 Vincent Tshituka, 20 Dillon Smit, 21 Tyrone Green, 22 Wandisile Simelane
Date: Friday, August 24
Venue: Ellis Park, Johannesburg
Kick-off: 19:00 local (17:00 GMT)
Match Officials: TBC