The European champions are top of Group E having beaten Genk 2-1 last time out.
Jurgen Klopp’s men will be eager to reach the Round of 16 with a game to spare but know that won’t be easy against the Serie A side.
Liverpool lost to Napoli in their opening Champions League game this season, going down 2-0 after goals from Dries Mertens and Fernando Llorente.
Liverpool vs Napoli: Date and kick-off time
The fifth game in Group E will be held on Wednesday, November 27 and will kick-off at 8pm GMT.
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Liverpool beat Crystal Palace in the Premier League on Saturday while Napoli drew with AC Milan in Serie A.
The Reds will make the trip to Austria to face Red Bull Salzburg in their final group game next month.