Ireland head coach Joe Schmidt has named Joey Carbery at 10 for their November international opener against Italy in Chicago on Saturday.
Carbery is alongside Luke McGrath in the half-backs while Bundee Aki and Garry Ringrose line up in a strong combination at Soldier Field.
There are two uncapped players included in the 23-man squad.
Rhys Ruddock will captain the side having previously worn the armband for the duration of the 2017 June tour of the USA and Japan. He is joined in the back-row by Josh van der Flier and Jack Conan.
Andrew Porter and Jack McGrath pack down either side of Niall Scannell in the front-row with Tadhg Beirne and Quinn Roux teaming up in the second-row.
Jordon Larmour starts at full-back with Andrew Conway and Jacob Stockdale on the wings.
The uncapped Ross Byrne and Will Addison are named in the replacements along with Sean Cronin, Dave Kilcoyne, Finlay Bealham, Devin Toner, Jordi Murphy and John Cooney.
Ireland: 15 Jordan Larmour, 14 Andrew Conway, 13 Garry Ringrose, 12 Bundee Aki, 11 Jacob Stockdale, 10 Joey Carbery, 9 Luke McGrath, 8 Jack Conan, 7 Josh van der Flier, 6 Rhys Ruddock (c), 5 Quinn Roux, 4 Tadhg Beirne, 3 Andrew Porter, 2 Niall Scannell, 1 Jack McGrath
Replacements: 16 Sean Cronin, 17 Dave Kilcoyne, 18 Finlay Bealham, 19 Devin Toner, 20 Jordi Murphy, 21 John Cooney, 22 Ross Byrne, 23 Will Addison
Date: Saturday, November 3
Venue: Soldier Field, Chicago
Kick-off: 15:00 local (20:00 GMT)
Referee: Nigel Owens (Wales)
Assistant referees: Romain Poite (France), Alexandre Ruiz (France)
TMO: David Ardrey (USA)