The Reds lead second-placed Leicester by 13 points and are yet to be beaten in the Premier League this season.
Jurgen Klopp’s side will be favourites to keep their impressive run going against a Tottenham side without influential duo Harry Kane (hamstring) and Moussa Sissoko (knee).
Both players sustained injuries in Tottenham’s 1-0 defeat at Southampton on New Year’s Day.
And with Spurs still without captain Hugo Lloris, who is recovering from a serious elbow injury, Sadio Mane and co will fancy their chances of getting on the score sheet.
In a game which is LIVE on talkSPORT, we look at how both sides could line up.