Jonny May and Will Spencer return to the Leicester Tigers team for Friday’s Champions Cup game against the Scarlets at Welford Road.
England international wing May, who has five tries already this season, is back after a shoulder injury and lock Spencer is in his first game back after suspension.
Harry Wells makes his 50th appearance for the club and joins Spencer at lock, with Mike Williams reverting to a role in the back row alongside Guy Thompson and Sione Kalamafoni this week. Brendon O’Connor and David Denton are both ruled out by injury.
Jonah Holmes, called up to the Wales squad for the first time this week, continues at full-back and Jordan Olowofela is named on the wing after making his European debut against Ulster last Saturday.
Graham Kitchener returns to the matchday squad for the Round 2 fixture in Pool 4 and there is also a place among the replacements for Argentina international prop Facundo Gigena.
The Scarlets hand a European debut to Wales U20 wing Ioan Nicholas as they head into the vital Heineken Champions Cup clash with Leicester Tigers at Welford Road on Friday evening.
The unavailability of Rhys Patchell because of concussion and Angus O’Brien because of a knee problem that is set to keep him out for the majority of the season means Dan Jones comes in at fly-half.
Steff Hughes, normally a centre, provides the back-up at No. 10 from the bench.
Up front, the lock options are particularly stretched. Steve Cummins (concussion) and Jake Ball (dead leg) are both sidelined, while Aaron Shingler, who could have featured in the engine room in a crisis, is a long-term casualty.
A further change from the side that lost to Racing sees Josh Macleod come into the back row at the expense of Ed Kennedy. Macleod features at openside, allowing Will Boyde to move to No. 8 and Blade Thomson to figure at blindside.
Leicester Tigers: 15 Jonah Holmes, 14 Jonny May, 13 Manu Tuilagi, 12 Kyle Eastmond, 11 Jordan Olowofela, 10 George Ford, 9 Ben Youngs, 8 Sione Kalamafoni, 7 Guy Thompson, 6 Mike Williams, 5 Will Spencer, 4 Harry Wells, 3 Dan Cole, 2 Tom Youngs (c), 1 Greg Bateman
Replacements: 16 Tatafu Polota-Nau, 17 Facundo Gigena, 18 Joe Heyes, 19 Graham Kitchener, 20 Tommy Reffell, 21 Sam Harrison, 22 Matt Toomua, 23 Adam Thompstone
Scarlets: 15 Leigh Halfpenny, 14 Ioan Nicholas, 13 Jonathan Davies, 12 Hadleigh Parkes, 11 Steff Evans, 10 Dan Jones, 9 Gareth Davies, 8 Will Boyde 7 Josh MacLeod 6 Blade Thomson 5 David Bulbring 4 Tom Price 3 Samson Lee, 2 Ken Owens (c), 1 Wyn Jones
Replacements: 16 Ryan Elias, 17 Phil Price, 18 Werner Kruger, 19 Josh Helps, 20 Uzair Cassiem, 21 Sam Hidalgo-Clyne, 22 Steff Hughes, Paul Asquith
Date: Friday, October 19
Venue: Welford Road
Kick-off: 19:45 BST (18:45 GMT)
Referee: Romain Poite (France)
Assistant referees: Vincent Blasco Baqué (France), Stéphane Boyer (France)
Television match official: Denis Grenouillet (France)