France have been dealt a blow ahead of the November internationals with the news that Bernard le Roux and Wesley Fofana have been ruled out with injury.
Racing 92 loose forward Le Roux sustained a fractured cheekbone in the 44-12 Champions Cup win over Ulster on Saturday.
Meanwhile, Clermont centre Fofana is struggling to shake off a thigh injury in time for the Tests against South Africa, Argentina and Fiji.
Les Bleus head coach Jacques Brunel has called up Toulouse back Yoann Huget and Lyon forward Felix Lambey as their replacements.