England head coach Eddie Jones has named Ben Te’o at inside centre for their November Test opener against South Africa at Twickenham on Saturday.
Te’o has barely featured for Worcester Warriors, playing just 28 minutes in a Challenge Cup encounter, but will partner Henry Slade in the midfield.
Dylan Hartley and Owen Farrell, who starts at fly-half instead of George Ford, are named as co-captains in a starting XV which includes 413 caps.
Alec Hepburn will make his starting debut for England while uncapped players Zach Mercer and Ben Moon are named among the replacements.
George Kruis, Jack Nowell and Te’o are included for the first time since last season’s Six Nations.
Manu Tuilagi is named on the bench having last played for England against Wales in the 2016 Six Nations.
“We’ve become very well organised in our set piece and have done a lot of good work in Portugal over the last week,” said Jones. “We have put in a new defence system and our attack looks more organised than it was on the South Africa tour.”
On taking on South Africa, Jones said: “Against South Africa you have got the physical battle up front and then you have to be tactically smart in how you attack against them. We need to find ways to gain momentum, then once we find momentum, convert that to points.
“We are really excited to be back at Twickenham Stadium. It’s been a long time and we can’t wait to play in front of 82,000 fans.”
England: 15 Elliot Daly, 14 Jack Nowell, 13 Henry Slade, 12 Ben Te’o, 11 Jonny May, 10 Owen Farrell (cc), 9 Ben Youngs, 8 Mark Wilson, 7 Tom Curry, 6 Brad Shields, 5 George Kruis, 4 Maro Itoje, 3 Kyle Sinckler, 2 Dylan Hartley (cc), 1 Alec Hepburn
Replacements: 16 Jamie George, 17 Ben Moon, 18 Harry Williams, 19 Charlie Ewels, 20 Zach Mercer, 21 Danny Care, 22 George Ford, 23 Manu Tuilagi
Date: Saturday, November 3
Venue: Twickenham, London
Kick-off: 15:00 GMT
Referee: Angus Gardner (Australia)
Assistant referees: Jerome Garces (France), Ben Whitehouse (Wales)
TMO: Olly Hodges (Ireland)