City have dominated the competition in recent years, winning it in four of the past six seasons.
They beat Chelsea on penalties last term to lift the trophy and will be looking to get past neighbours United and reach another final in March.
United crashed out in the third round last season and Ole Gunnar Solskjaer will be eager to bring the winning ways back to the club.
Leicester or Aston Villa will await the victors of the two-legged Manchester derby at Wembley later this year.