Jurgen Klopp’s Reds, still unbeaten this season, saw off Bournemouth last weekend and are eight points clear at the top.
Relegation-threatened Watford, meanwhile, are still propping up the rest of the table with only one win all season.
They played out a goalless draw with Crystal Palace last time out and face a huge task to get anything at Anfield.
The Hornets have lost by five goals on each of their last three trips to the Kop.
talkSPORT’s GameDay special kicks off on Merseyside this weekend as we bring you full coverage of Liverpool vs Watford.