Liverpool are usually the favourites to beat their local rivals and very few would bet against them getting the three points in the 234th Merseyside Derby.
The Reds have won 13 of their 14 Premier League games this term, while the Toffees are just two points above the relegation zone.
Meanwhile, the Premier League leaders have home advantage and also have an extra day’s preparation as they played Brighton on Saturday while their rivals faced Leicester on Sunday.
Everton also have a dreadful record against Liverpool in recent seasons and have not beaten them since October 2010.
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They have not won at Anfield, where they are playing on Wednesday night, since September 1999.
A lot has happened in the two decades since Everton last tasted victory at Liverpool’s home and talkSPORT.com has taken a trip down memory lane to look back at that game and what else was going on in the world at the time.