Marcus Rashford’s stunning free-kick was the difference between the two sides as the Red Devils ran out 2-1 victors to advance to the quarter-finals of the competition – ending the west London side’s seven-game winning streak in the process.
Frank Lampard could become just the second Chelsea manager to win seven successive away games in all competitions – after Bobby Campbell in 1989 – should his side take away all three points from Vicarage Road.
Meanwhile, there is the sense that Watford are starting to head in the right direction under the recently-appointed Quique Sanchez Flores.
With that said just one victory has come from their last 16 Premier League fixtures, a period which began in the aftermath of their dramatic FA Cup semi-final success over Wolves in April.
That elusive first top-flight win needs to come sooner rather than later, with the Hornets four points adrift off 17th-placed Newcastle.
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Below, talkSPORT.com predicts how both sides will line up for the 5:30pm kick-off – which is LIVE on talkSPORT.