Already without Harry Kane, Eric Dier, Serge Aurier, Harry Winks, and Erik Lamela, manager Mauricio Pochettino also lost Moussa Sissoko to injury, a groin issue forcing him off in the first half at the Etihad Stadium on Wednesday.
Spurs somehow managed to make it through the match, dropping Dele Alli into a deeper role and using Fernando Llorente as a target man, where the Spaniard made a vital contribution with their ‘winning’ goal in the tie, despite being relatively poor when he took to the field.
With Sissoko being assessed and unlikely to play, or start at least, Pochettino now must make some big decisions which could ultimately alter the course of the Premier League title.
Liverpool’s run-in leaves them as favourites, just, but should City get revenge on Tottenham Hotspur, the ball would firmly be in Pep Guardiola’s court.
The Reds and the Anfield faithful, though, may fear the team Spurs might turn out on Saturday afternoon as they possibly rotate.