Full-backs Ashley Young and Luke Shaw are suspended, while Antonio Valencia is not fully fit.
It means Ole Gunnar Solskjaer could be forced into playing centre-halves Phil Jones and Marcos Rojo out of position.
Two defeats in their past three Premier League games have seen United drop to sixth, three points behind fourth-placed Tottenham.
Red Devils boss Solskjaer told MUTV: “We don’t have full-backs this week.
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“Not too many as we’ve lost Luke and Ashley through suspension. Antonio is still not fit.
“Maybe Matteo [Darmian] will be available for the bench and Rojo has been training for a while.
”He’s available and we’ve got Jonah [Phil Jones], who could also play there.
“Rojo needed to get out on the big pitch [in the Under-23s’ game against West Brom last Friday] so he could have that game but we’ve had a couple of practice matches so let’s see what we decide.”
Meanwhile, United are set to still be without midfielders Ander Herrera (thigh) and Nemanja Matic (illness).