Ross Cronje and Aphiwe Dyantyi will start for the Lions against the Jaguares at Ellis Park on Saturday as they look to make a third successive semi-final.
They have replaced Courtnall Skosan and the injured Nic Groom in the starting line-up as boss Swys de Bruin makes two changes to the XV.
De Bruin has also altered the bench slightly following Groom’s enforced absence with Dillon Smit among the replacements, while prop Dylan Smith is selected ahead of Jacobie Adriaanse.
The Lions and Jaguares have one win apiece from their respective clashes in 2018 but the hosts claimed a 47-27 triumph in Johannesburg in Round Two.
Lions: 15 Andries Coetzee, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Harold Vorster, 11 Aphiwe Dyantyi, 10 Elton Jantjies, 9 Ross Cronjé, 8 Warren Whiteley (c), 7 Cyle Brink, 6 Kwagga Smith, 5 Franco Mostert, 4 Marvin Orie, 3 Ruan Dreyer, 2 Malcolm Marx, 1 Jacques van Rooyen
Replacements: 16 Corne Fourie, 17 Dylan Smith, 18 Johannes Jonker, 19 Lourens Erasmus, 20 Marnus Schoeman, 21 Dillon Smit, 22 Courtnall Skosan, 23 Howard Mnisi
Date: Saturday, July 21
Venue: Ellis Park, Johannesburg
Kick-off: 15:05 local (14:05 BST, 13:05 GMT)
Referee: Jaco Peyper
Assistant Referees: Marius van der Westhuizen, Egon Seconds
TMO: Marius Jonker