Argentina head coach Mario Ledesma has brought experienced lock Tomas Lavanini into the starting line-up for the game against South Africa in Mendoza.
Lavanini replaces Matias Alemanno, who has dropped to the bench, in the XV and will partner Guido Petti in the second-row.
Ledesma has otherwise kept faith with the team that went down to the Springboks in Durban. The only other alterations are among the replacements as Facundo Bosch, Tomas Cubelli and Jeronimo de le Fuente are all included.
Out go Diego Fortuny, Martin Landajo and Santiago Gonzalez Iglesias with Argentina looking for more impact from the substitutes. They failed to produce the required performance off the bench in the opening weekend of the Rugby Championship as South Africa dominated the second half.
Argentina: 15 Emiliano Boffelli, 14 Bautista Delguy, 13 Matias Moroni, 12 Bautista Ezcurra, 11 Ramiro Moyano, 10 Nicolas Sanchez, 9 Gonzalo Bertranou, 8 Javier Ortega Desio, 7 Marcos Kremer, 6 Pablo Matera, 5 Tomas Lavanini, 4 Guido Petti, 3 Juan Figallo, 2 Agustin Creevy (c), 1 Nahuel Tetaz Chaparro
Replacements: 16 Facundo Bosch, 17 Santiago Garcia Botta, 18 Santiago Medrano, 19 Matias Alemanno, 20 Tomas Lezana, 21 Tomas Cubelli, 22 Jeronimo de la Fuente, 23 Juan Cruz Mallia
Date: Saturday, August 25
Venue: Estadio Malvinas Argentinas, Mendoza
Kick-off: 16:10 local (20:10 BST, 19:10 GMT)
Referee: Angus Gardner (Australia)
Assistant referees: Ben O’Keeffe (New Zealand), Andrew Brace (Ireland)
TMO: Simon McDowell (Ireland)