Fly-half Paolo Garbisi has been brought straight into the Italy team for their Six Nations fixture against Ireland in Rome on Saturday.
The 22-year-old missed their opening two matches of the tournament through injury but proved his fitness by playing 30 minutes for Montpellier last weekend.
Impressive return
He assisted a try during his time on the field as they succumbed 31-21 to Lyon in the Top 14.
Garbisi combines with Stephen Varney at half-back, while Tommaso Allan, who started against France and England, drops to the Italy bench.
There is just one more alteration in the backline from the team that went down to the Red Rose, with Pierre Bruno coming in for Luca Morisi.
Bruno takes his place on the left wing with Menoncello moving to centre to partner Juan Ignacio Brex in the midfield.
One change in the pack
Up front, head coach Kieran Crowley has returned to the combination which impressed against Les Bleus, with Simone Ferrari coming in for Marco Riccioni.
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Giacomo Nicotera and Danilo Fischetti complete the front-row and they are supported by locks Niccolo Cannone and Federico Ruzza.
With Sebastian Negri, Michele Lamaro and Lorenzo Cannone the loose trio, it means that Crowley has gone for the same back five for the third Six Nations match in a row.
On the bench, Jake Polledri is injured which means Giovanni Pettinelli comes into the 23, and he is joined by fellow replacements Luca Bigi, Federico Zani, Riccioni, Edoardo Iachizzi, Alessandro Fusco and Morisi for the encounter with Ireland.
Italy: 15 Ange Capuozzo, 14 Edoardo Padovani, 13 Juan Ignacio Brex, 12 Tommaso Menoncello, 11 Pierre Bruno, 10 Paolo Garbisi, 9 Stephen Varney, 8 Lorenzo Cannone, 7 Michele Lamaro (c), 6 Sebastian Negri, 5 Federico Ruzza, 4 Niccolò Cannone, 3 Simone Ferrari, 2 Giacomo Nicotera, 1 Danilo Fischetti
Replacements: 16 Luca Bigi, 17 Federico Zani, 18 Marco Riccioni, 19 Edoardo Iachizzi, 20 Giovanni Pettinelli, 21 Alessandro Fusco, 22 Luca Morisi, 23 Tommaso Allan
Date: Saturday, February 25
Venue: Stadio Olimpico, Rome
Kick-off: 15:15 local (14:15 GMT)
Referee: Mike Adamson (Scotland)
Assistant Referees: Wayne Barnes (England), Craig Evans (Wales)
TMO: Marius Jonker (South Africa)