The U’s are the lowest ranked club left in the cup and are set to face five-time winners United at Old Trafford.
Colchester beat Crawley Town to reach the quarter-finals while the Red Devils saw off Southampton.
Now Ole Gunnar Solskjaer’s side will be out to avoid a huge giant killing and reach the semis.
Can Colchester spring a surprise or will United ease through? talkSPORT will bring you all the action live.
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